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The closing of the extracellular regions by the ECD and the reorganization of the TMD conformation interfere with the binding of GLP-1 to the orthosteric pocket in the inactive state of full-length GLP-1R (Supplementary Fig

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Consume the contents of one sachet as is or dissolve in a small amount of cold, still water

[1] [2] Saxenda is administered as a once-daily subcutaneous injection, with the dose titrated weekly from 0.6 mg to a maintenance dose of up to 3.0 mg