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Mfn2 exists in two distinct functional forms, the compressed inactive form and the expanded active form, which are associated with different biological roles (Franco et al., 2016)

GLP-1 receptor agonists such as semaglutide (marketed under brand names Ozempic, Wegovy, and Rybelsus) and the dual GIP/GLP-1 agonist tirzepatide (marketed under brand names Mounjaro and Zepbound) are FDA-approved prescription medications for specific uses in type 2 diabetes management and, in some cases, chronic weight management

Joseph Rizzo, MD, who led the study, noted how physicians should let patients know that NAION is a risk associated with semaglutide, though potentially uncommon

doi: 10.1016/j.jdiacomp.2017.05.013 51 Moschovaki FilippidouFKirschAHThelenMKtszeriMArtingerKAringerIet al