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doi: 10.1016/j.cmet.2022.07.013

Additionally, carbohydrates induce GLP-1 secretion by changing the gut microbiota and subsequently improving the production of bacteria-derived molecules such as SCFAs, and bile acids [173]

Think of NF-kB sort of like a firefighter, it sits inside cells, waiting for a signal that something is wrong (like an injury, an infection, or stress) only then does it activate and tell the cell how to defend itself