It works by simultaneously activating three receptors glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors producing significant reductions in body weight and improvements in metabolic markers
Accordingly, real-world series confirmed that constipation occurs more frequently in patients with overweight/obesity than with T2D [50]
Noteworthy, due to the multifactorial nature of xerostomia, any association between semaglutide and reduced salivary function must be interpreted with caution until controlled studies accounting for metabolic, autoimmune, neurological, pharmacologic, and age-related confounders are available
Surg Obes Relat Dis 14(6):741747 King WC, Hinerman AS, Courcoulas AP (2020) Weight regain after bariatric surgery: a systematic literature review and comparison across studies using a large reference sample