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Because oral glutathione supplements have historically demonstrated poor bioavailability and are rapidly broken down by enzymes in the gastrointestinal tract, the body relies heavily on intracellular de novo synthesis to maintain its protective antioxidant pools

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h , Uptake of [ 3 H]GSH after incubation with 400 M unlabelled GSH and 4 M [ 3 H]GSH into ER at indicated times