Current evidence suggests no consistent increase in CA or major adverse pregnancy outcomes with inadvertent early exposure, although the available data remain limited and largely observational

patients should be advised to seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : cholelithiasis and cholecystitis have been reported with GLP-1 receptor agonists [11] [22] Diabetic retinopathy complications : particularly in patients with pre-existing retinopathy who experience rapid improvement in glucose control Common adverse effects of Januvia include: Upper respiratory tract infections and nasopharyngitis Headache and gastrointestinal disturbances (though generally milder than with GLP-1 agonists) Rare but serious risks : acute pancreatitis, severe joint pain, hypersensitivity reactions, and bullous pemphigoid (a serious skin condition) When used together, there is a theoretical increased risk of gastrointestinal side effects , particularly nausea, as both medications influence gut hormone pathways

In the same announcement, Coherus reported that in the process of inspecting three sites in China enrolling patients for two pivotal trials of its PD-1 antibody toripalimab in recurrent nasopharyngeal carcinoma (NPC), the FDA identified one observation
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