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Most people start with 2mg weekly and gradually increase to 4mg, then 8mg, and potentially up to 12mg as the maximum dose

Pedrazzini T, Pralong F, Grouzmann E (2003) Neuropeptide Y: the universal soldier

The cell growth medium was replaced by a medium containing 2% FBS DMEM without sodium bicarbonate 1 h before the Seahorse MitoStress assay was performed