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Blood and tissue distribution After transfer into blood, lipophilic Tac is mainly bound to red blood cells through the FK506 binding proteins (FKBP), leading to a 4-114-fold higher Tac concentration in full blood compared to plasma (61, 62)

Moreover, Up-regulation of -aminobutyric acid (GABA) levels in the brain is considered to be related to the pathological mechanism of depression (104)

Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma

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