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Funding This work was supported by funding from the Sanming Project of Medicine in Shenzhen (SZSM201612051), the opening project of State Key Laboratory of Explosion Science and Technology (Beijing Institute of Technology, KFJJ22-16M), National Nature Science Foundation of China (81970467), and CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-1-003)

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Because Gd is X-linked (discussed later in this chapter), males can be only normal hemizygotes ( Gd +) or deficient hemizygotes ( Gd )

Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease