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Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

It creates a lot of demand, and it creates openings for people to exploit that demand, Jay tells TODAY.com

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Clinical trials show tirzepatide producing slightly greater average weight loss, with participants losing 15 to 21 percent of body weight compared to 15 to 17 percent with semaglutide