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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

PLoS ONE 9 , e104397

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Despite these shared traits, GS-S transferases coded for by the same genotype can have differing (though occasionally overlapping) substrate specificity and activity depending on the tissue they are found in and there is much research trying to discover what effect these genetic differences may have on an individuals idiosyncratic response to certain substances such as carcinogens