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The post says personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 must be evaluated first, and that GLP-1 agonists are contraindicated in those populations regardless of age

Certain conditions, such as pregnancy, breastfeeding, or a history of severe gastrointestinal or thyroid disease, may affect eligibility

Specifically, patients on GLP-1RA or combination therapy exhibited greater reductions in body mass index (BMI), central systolic blood pressure (SBP), and arterial stiffness as assessed by pulse wave velocity (PWV)