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Understanding these effects and how administration timing may influence them can improve your treatment experience

established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present

In direct cell-cell contact and indirect mechanisms, tumour cells induce nonmalignant cells, such as fibroblasts, endothelial cells, and immune cells, to migrate to the TME [185]

Expert Opin Ther Targets 22:715726