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The levels of ADP-ribose (ADPR), produced from the hydrolysis of ADP-ribosylation units by ADP-ribosyl-acceptor hydrolases (55, 56), were higher in placentas from the LPS-induced PE model and normalized with NR treatment, indicating that NR intervention likely did not increase ADP-ribosylation hydrolysis to result in lower ADP-ribosylation levels (Fig 4D)

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[1] Timing of administration is flexible, though some people prefer taking B12 in the morning