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These intrinsic properties are also known to change plastically during development or under pathological conditions, suggesting that MTN dysfunction can contribute to abnormal mastication or altered nociception (Turman et al., 1999)

The magnitude of difference reflects each drug's biological action

Although direct inhibition of GPX4 has emerged as a canonical strategy to induce ferroptosis, its clinical translation remains challenging owing to systemic toxicity and poor pharmacological properties 124