Metabolic rate (influenced by thyroid function, body composition, and physical activity) also modulates drug clearance, with higher metabolic rates potentially shortening half life and lower rates extending it
when all GSH has been spent, NAPQI begins to bind to certain enzymes like N-10 formyltetrahydrofolate dehydrogenase and glutamate dehydrogenase, reducing their activity and killing the cells in the process
2020;9(Suppl 2):S149-S159
It is commonly studied in relation to copper-peptide signaling, extracellular matrix research models, tissue-response pathways, angiogenesis-related mechanisms, inflammatory signaling environments, epithelial peptide interactions, cell-migration pathways, and actin-binding protein biology