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American Academy of Neurology guidelines on treating painful DPN recommend that clinicians evaluate oral, topical and nonpharmacologic therapies for patients with painful diabetic polyneuropathy, and emphasizes switching between drug classes rather than trying multiple agents within the same class if one fails [63]

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Don't introduce multiple new peptides at once, as this makes it impossible to determine which compound causes any observed effects or side effects

10.2174/1381612824666180608101119 61 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997)