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Animal data covers relatively short treatment cycles, and extrapolating beyond that requires clinical judgment
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They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects
When used in combination, these compounds support exploration of convergent signalling responses, matrixassociated processes, and peptidemetal interactions under controlled laboratory conditions
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