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Choose phentermine if you: Need a lower-cost appetite tool with fast impact Prefer a tablet over injections Want a short-term reset with coaching and accountability Consider GLP-1s if you: Aim for larger total body-weight loss and can tolerate injections or oral GLP-1 dosing Have metabolic comorbidities where GLP-1 therapy provides additional benefits Have coverage/savings that reduce out-of-pocket cost Are willing to make a permanent financial commitment, as all studies show a very high rate of weight regain when stopping GLP-1s
Gutzwiller JP, Gke B, Drewe J, Hildebrand P, Ketterer S, Handschin D, et al
To detect GLP-1 secretion from enteroendocrine cell supernatants, we exploit a reporter cell line that expresses the recombinant GLP-1 receptor in combination with the chAMPion reporter system in a CHO background
However, in people with T2D and MASLD, 24 weeks of efinopegdutide 10 mg reduced liver fat content by 72.7% compared to 42.3% reduction with semaglutide 1 mg despite similar WL achieved with both interventions [79]
