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Less common effects include darkening of existing moles and freckles, and appetite suppression severe enough to cause unintended weight loss

Conversion of calcidiol to its biologically active form, calcitriol, occurs through the activity of a specific 25-hydroxyvitamin D 3 1--hydroxylase (commonly just called 1--hydroxylase) present in the inner mitochondrial membrane of cells of the proximal convoluted tubules of the kidneys, and in several extrarenal sites such as in keratinocytes, macrophages, and placenta

5, 6 and 7 and Supplementary Figs

they are early structural signals of an entire ecosystem reorienting around a far more demanding, nutritionally literate diner