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Given the identification of 19,713 crotonylation sites across 7,637 proteins in hepatocellular carcinoma (HCC) [65], follow-up studies could further investigate butyrates regulatory effects on these proteins crotonylation modifications

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Dual GIP/GLP-1 agonists now represent the highest-revenue growth segment in the GLP-1 weight loss drug market at 18.4% CAGR , with tirzepatide generating USD 18.3 billion in 2025 revenue through Zepbound and Mounjaro surpassing Eli Lillys entire insulin franchise within two years of commercial launch