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Mice lacking the clock activator Bmal1 in adipocytes ( Bmal1 knockout (KO)) displayed reduced mitochondrial OCR in response to pyruvate during the dark period (ZT14) compared with mice with an intact clock

Wongkitisophon P, Rattanakaemakorn P, Tanrattanakorn S, Vachiramon V

Both of those groups like to sleep a little later than the larks and go to bed earlier than the owls, but one of those two groups feels sluggish both morning and evening while the other has high energy levels at both times

There are encouraging signs that some pharmacological manipulations of mGluR have shown initial success in restoring impaired LTD and improving ASD-related behaviours in mouse models