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Qi-Feng Liu, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Given these intrinsic biological differences, histology-specific radiosensitivity may influence how dosimetric advantages of hydrogel spacing translate into clinical outcomes