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They are also frequently obtained from routinely discarded human tissues, such as extracted third molars and deciduous teeth, making them highly accessible and raising minimal ethical concerns

Then in 2019, a meta-analysis study tried to clarify the OS marker profile in ALS patients: the authors demonstrated that 8-OHdG and MDA were significantly increased in the peripheral blood of ALS patients when compared with control subjects, while GSH levels were significantly reduced

Interestingly, systemic administration of adiponectin in a lymphedema mouse model effectively reduced lymphedema by inducing lymphatic vessel formation (41)