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doi: 10.1126/scitranslmed.adl3381 47 BryantCESutherlandSKongBPapadimitriousMSFrommPDHartDNJ

Allopurinol and oxypurinol differ from febuxostat in their capacity for inhibition of the oxidized and reduced forms of the xanthine oxidase/xanthine dehydrogenase enzyme, but the clinical pharmacologic ramifications in typical medical practice of such differences are not yet clear