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Recent studies highlight the effectiveness of NAC in mitigating ROS, fostering pro-repairative microenvironment and enhancing the osteogenic potential and immune regulatory function of cells, which offers a promising role in the treatment of bone injuries and bone tissue engineering (Supplementary Figure S1B)

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however, their development has proceeded less successfully than expected due to the melanocortin pathways role in increasing heart rate and blood pressure as well as induction of penile erection [58,59]