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When compounds are produced in a lab, you never know how well they will interact with a biological system (like your body)

Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation

We identify the conformationally flexible TM1 as a key helix with dual function, as residues on this helix contribute to both Na + -binding and extracellular gating formation

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