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Although the treatment policy estimand (which uses data regardless of treatment discontinuation and rescue medication use) was the primary estimand in PIONEER 2 and PIONEER 3, it was inappropriate to use it for a long-term cost-effectiveness analysis without adjusting for the clinical effects and associated costs of rescue medication used during the study

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Treatment with liraglutide-a once-daily GLP-1 analog-does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug

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