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Large doses of caffeine may interfere with the ergogenic effects of creatine [47]

R&D Systems, Minneapolis, MN) in RPMI-1640 (Gibco, Detroit, MI) medium supplemented with 2% penicillin/streptomycin (Gibco), 20 mM HEPES (Gibco) and 5% pooled normal human heat-inactivated and sterile-filtered AB serum (Innovative Research, Novi, MI) for 7 days, with a media change on day 5 with fresh M-CSF (10 ng/mL)

The primary pathogenesis of PD involves the degeneration and death of dopaminergic neurons in midbrain substantia nigra, as well as the presence of abundant filamentous inclusions of -syn in the form of Lewy bodies and Lewy neurites (Yang et al., 2022

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