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By the time most patients are in their late 30s or 40s, pineal calcification and reduced melatonin synthesis have already begun degrading sleep architecture, particularly the slow-wave deep sleep phases where cellular repair, growth hormone release, and memory consolidation occur

Where each stands and what the data shows The reported results put them in a rough order on efficacy, though cross-trial comparisons are not definitive

WebMD (2020)

The importance of being CG-rich and the curious case of Sox2 Transcription factors involved in adult neurogenesis are single-exon genes, for example, Sox2 , Sox4 , and Sox11 , or two-exon genes, for example, Ngn2 , NeuroD1, and NeuroD2 , that are embedded in long stretches of high CG densities (CpG islands)