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Gastrointest Pathophysiol

OXM has a dual role as an agonist for GLP1R (glucagon-like peptide-1 receptor) and GCGR (glucagon receptor), leading to decreased appetite and increased human energy expenditure

Losing excess weight can improve overall health and may help reduce the impact of conditions such as high blood pressure, prediabetes, type 2 diabetes, sleep apnea, elevated cholesterol, and joint discomfort

Given the fairly short half-life of unbound IGF-1 in serum (i.e., 510 min), binding to an IGF binding protein (IGFBP-3 is the most prevalent) in serum or in ECM increases IGF-1 half-life to around 25 min (Allard and Duan, 2019), leading to the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) (O'Neill et al., 2015)