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To bring patients to each of the four targets based on the PIONEER 4 trial, 2.1, 1.5, 2.1, and 1.6 patients needed to be treated with oral semaglutide 14 mg, while 2.3, 1.6, 2.9, and 1.9 patients needed to be treated with liraglutide 1.8 mg (Fig