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NMN enters cells where special enzymes called NMN adenylyltransferases (NMNATs) turn it into NAD+ right away [7]

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High soil pH, high manganese or high iron levels can reduce cobalt transfer from the soil to the plant

Based on such evolving biology, the 3Ts protocol integrates all available therapeutic tools, pharmacologic oxygenation (tadalafil), intralesional biologic regeneration (tunneling), and mechanical remodeling (traction) to promote true tissue restoration rather than simple deformity correction (Table 1)