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Description

The effect is most noticeable when you first start and after each dose increase, then settles over time

Sobczyk-Krupiarz, M

Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )