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197,200 It is plausible that GLP-1 directly decreases appetite, as this would allow ingested nutrients to be digested and prevent hyperglycaemia/hyperlipidaemia or undesirable nutrient storage by more ingestion of nutrients

J Neurochem 159:867886 Ma X-l, Ding Y, Wu L-M, Wang Y-X, Yao Y, Wang Y-X, Zhang Y-G, Niu J-Q, He X-X, Wang Y-Q (2021) The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice

This in turn destabilizes histone-DNA binding and assists transcription

Deficiencies are generally seen only after long antibiotic therapies which deplete the intestinal microbiota or following excessive consumption of raw eggs