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Synergistic metabolic effect Some products contain ingredients such as caffeine and methylnicotinate esters, which can activate adenylate cyclase (AC), increase intracellular cAMP levels, and thereby activate hormone-sensitive lipase (HSL), accelerating fat mobilization

The trial began in March 2021 and concluded in January 2024, comprising a two-week screening period, a 12-week run-in period, and a 56-week treatment period, followed by a 26-week follow-up period

This happens because the body adapts to the mechanism over time, which may reduce responsiveness

Bulk RNA sequencing confirms that ECM types elicit significant changes in the expression of genes associated with MC pigmentation and differentiation Our data so far indicate that ECM composition modulates MITF localization and activity in MCs, suggesting that ECM components may influence MITF-regulated transcriptional programs