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Although many mild cases resolve over time and with dietary modification, meta-analyses and systematic reviews indicate that a notable subgroup, estimated to be between 1% and 10%, experiences severe and persistent symptoms that do not adequately respond to dietary measures and, therefore, require additional management [94]

There is not enough data to show that it is safe for pregnant or nursing individuals

A greater than 10% reduction in SBP was observed in 35% of participants receiving empagliflozin, in 39% of those receiving losartan, and in 43% among participants on combination therapy

Some have a faster metabolism and tend to metabolize semaglutide faster than others, while others with a slower metabolism may metabolize it more slowly