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Long-term data on phentermine remains limited because the FDA historically approved it for short-term use only (12 weeks or less), though some physicians prescribe it off-label for extended periods

Several studies have indicated that PPAR is a crucial regulator of lipid metabolism in the liver through the activation of target genes (Kersten et al., 1999

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Then, cells were incubated with a 1:200 dilutions of primary anti--H2AX antibody (ABclonal Technology, Wuhan, China) overnight at 4 C, followed by three washes with PBS and incubation with FITC-labeled goat anti-rabbit IgG antibody for 1 h and mounted with DAPI [32]