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Web of Science, PubMed, and Cochrane Library from September 2018 to June 2020 were systematically searched by two investigators, and the published date for searched papers from the databases ranged from June 1990 to June 2020

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The canonical axis is governed by redox-tunable cysteines in IKK (Cys179) and in the DNA-binding cores of p65 (Cys38) and p50 (Cys62)