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Meanwhile, side effects increase more linearly with dose
For example, ROS can facilitate the extrinsic apoptosis pathway through negative regulation of the cellular FLICE-inhibitory protein (Wang et al., 2008) and can induce intrinsic apoptosis pathways by triggering quick release of Cyt-c (Madesh and Hajnoczky, 2001) and regulating the Bcl-2 protein family (Burlacu, 2003)
Active infections and uncontrolled chronic conditions should not be present in the patients
Failure to do so may lead to Vitamin B12 deficiency, which can cause health problems
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