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Zincs role in NETosis, the process by which neutrophils release extracellular traps (NETs) composed of DNA, chromatin, and granule proteins to trap pathogens, is equally complex

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Microscopically, BBS is characterized by the deposition of golden-brown granules, predominantly within the cytoplasm of smooth muscle cells of the muscularis propria , and occasionally in the muscularis mucosae and surrounding blood vessels, giving the intestines the typical gross appearance of brown bowel (Fig