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Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

Red Blood Cell Formation: Vitamin B12 is essential for producing red blood cells

But this is a difficult bit of biochemistry involving many raw materials and a tricky piece of biochemistry called the pentose phosphate shunt - it takes hours, possibly days, to restore normal ATP and this may explain the delayed fatigue and post-exertional malaise in CFS