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Mast cells (MCs) are stimulated and degranulate, releasing histamine, IL-6, IL-8, prostaglandin D2 and tumor necrosis factor-alpha (TNF)- together with IL-23 and IL-31 and other cytokines (48, 49)
Meal consumption continues to progress and delay meal termination, but as we pass that balancing point of negative/positive affect with the subjective feeling of fullness, the experience of the meal begins to take on a difficult to define, but clear state of malaise and nausea (4)
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