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In particular, genetic engineering has yielded excellent results
11, 12, 13 However, the LH is in fact the most potent self-stimulation center in the brain, and given that hungry/food-restricted rats self-stimulate even more than fed rats, an interaction between the metabolic status and reward may require processing by this brain nucleus, 7, 14 although it is also possible that stimulation of the median forebrain bundle, which connects the VTA to the NAc and runs through the LH, may contribute to the reinforcing effects of the intracranial self-stimulation studies
These treatments have been shown to decrease both beverage intake and cravings for alcohol and GLP-1, offering a promising new strategy for those grappling with substance dependence