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In a study conducted on 122 vitiligo Egyptian patients and 200 healthy controls, age- and gender-matched, the authors found a significant trend towards the combination of the GST-M1/GST-T1 double-null polymorphism and generalized vitiligo

However, the passage of 5-methyl-THF through the methionine cycle is limited, especially in situations with high intracellular 5-methyl-THF levels

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The carotenoids play an important role in protecting cellular membranes and lipoproteins from free-radical-induced oxidative stress