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It can potentially worsen weight obsession and risk in folks with anorexia, he adds. GLP-1 use in older adults There is no absolute cutoff when it comes to GLP-1 use in older adults, and these medications are generally considered safe in seniors, according to Mir Ali, MD, a board-certified bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California