GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide) carry the clinical evidence: STEP (semaglutide, NEJM 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
For details on insurance dynamics, see tirzepatide cost with insurance
Chronic Care Management (CCM) serves as the human layer, where Registered Dietitians manage side effects, titrate medications, and provide nutrition to prevent muscle wasting and ensure sustainable weight loss
Nevertheless, Neeland and his colleagues concluded that the available evidence suggests that the proportion of lean and muscle mass people lose while taking GLP-1s is in line with the proportion that people lose through diet and exercise alone, but called for additional research to confirm