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Tous les essais comportaient des limites importantes : petite taille 2-4 , courte dure 2-4 , leve de linsu 2-4 , absence danalyse par intention de traiter 2,3 , essai rdig et financ par le fabricant 4

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Retatrutide is a triple hormone receptor agonist, acting on three receptors simultaneously: GLP-1 (glucagon-like peptide-1) reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) enhances insulin secretion and may improve fat metabolism Glucagon receptor increases energy expenditure and promotes fat breakdown It is worth noting that glucagon receptor agonism can, in isolation, raise blood glucose levels