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The recent data provide evidence that GLP-1R activation affects the mechanisms of signal transduction associated with insulin resistance, energy homeostasis of the brain, neurogenesis, synaptic functioning, neuroinflammation and other cell responses to stress, pathological protein aggregates, proteostasis, the cerebrovascular system, and the BBB [42]

These organisms ferment the fiber and convert it into short-chain fatty acids (SCFAs)

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To address this, healthcare providers often reduce or discontinue these additional medications while closely monitoring blood sugar levels during the transition