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animal studies 52 have shown that intracerebral CRF injection can induce delayed gastric emptying and gastrointestinal dysmotility, exacerbating GERD-related functional symptoms

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While some medications may retain partial potency beyond their expiration dates, there is no reliable way for patients or clinicians to determine how much active ingredient remains in expired tirzepatide without laboratory analysis

This Review summarizes current knowledge regarding the neuroendocrine regulation of food intake by the gastrointestinal system, focusing on gastric distention, intestinal and pancreatic satiation peptides, and the orexigenic gastric hormone ghrelin